GETTING MY PKRRATING TO WORK

3B). R526 with the loop among αJ and αI anchors the C-terminal part of the activation loop by forming a salt bridge with E458 at the base of αEF. Q459 stabilizes the HRD motif by a hydrogen bond to the main chain carbonyl of R413. The idea of the activation phase is stabilized by a hydrogen bond in between Y454 and E480 from αfile. within the F